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Related post: Dr. Mark Tykocinski Chemist Staff Fellow Med. Staff Fellow LIG, NIAID COOPERATING UNITS (if any) T. Chused, LMI , NIAID, J. Purchase Trileptal Coe, Rocky Mountain Laboratory, NIAID, P. A. Cazenave, Institut Pasteur, Paris, France lab/branch Laboratory of Immunogenetics SECTION Immunogenetics Research Trileptal Online Secrinn INSTITUTE AND LOCATION NIAID, NIH, Bethesda, MD 20205 TOTAL MANYEARS: 2.4 PROFESSIONAL: 1.6 OTHER: 0. CHECK APPROPRIATE BOX(ES) D (a) HUMAN SUBJECTS n (al) Oxcarbazepine Trileptal MINORS n (a2) INTERVIEWS D (b) HUMAN TISSUES n (c) NEITHER SUMMARY OF WORK (200 words or less - underline keywords) A set of monoclonal antibodies prepared has been used in biochemical and functional analysis of rabbit lyirphoid cell subpopulations . Detailed study has defined a small group of the monoclonal antibodies which recognize distinct cell surface molecules and define among them si±)sets of T cells in the thymus and periphery as well as subsets of B cells. Immunoprecipitation of labeled surface rtDlecules has defined the antigens v^ile the cell sorter has been-used for cellular analysis. A number of antigen-specific rabbit T cell lines have been developed to characterize rabbit T cell responses Generic Trileptal to the These lines are being propagated for studies on The kappa group C streptococcus. antigen-binding molecules and restriction in antigen presentation. chain allotypes of wild rabbits (b97, b98) are under Trileptal Mg structural study in collaborative experiments. The hamster seirum protein FP (female protein) has also been partially characterized in sequence studies. I 19-12 PHS-6040 (Rev. 2-81) SMITHSONIAN SCIENCE INFORMATION EXCHANGE PROJECT NUMBER (Do NOT use this space) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOl-AI-00172-05 LIG PERIOD COVERED October 1. 1981 to September 30. 1982 TITLE OF PROJECT (80 characters or less) Structure and Synthesis of Peptides NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT Section Head PI: Dr. JohnE. Coligan Others: Dr. W.'Lee Maloy Staff Trileptal For Children Fellow Dr. Marie R. Van Schravendi j k Visiting Fellow LIG, NIA ID COOPERATING UNITS (if any) lab/branch Laboratory of Immunogeneti cs SECTION Membrane Antigen Structure INSTITUTE AND LOCATION NIAID, NIH, Bethesda, MP 20205 TOTAL MANYEARS: 2.5 PROFESSIONAL: 1 .5 1.0 CHECK APPROPRIATE BOX(ES) n Trileptal 900 Mg (a) HUMAN SUBJECTS n (al) MINORS D (a2) INTERVIEWS D (b) HUMAN TISSUES [i^(c) NEITHER SUMMARY OF WORK (200 words or less - underline keywords) Through protein and DNA sequence analyses, much information on Trileptal 300 Mg the primary structure of membrane bound proteins has accummalated over the past several years. It is proposed Trileptal Price to utilize this information to prepare antibodies reactive with defined portions of these molecules. This will be done by synthesizing 10-20 residue peptides that correspond to Trileptal Oxcarbazepine sections of the sequence of the membrane bound proteins. After coupling to a carrier Generic For Trileptal protein, antisera to these peptides will be prepared. In the case of Trileptal Generic transplantation and other lyrtphocyte antigens, these antibodies will be used to define sites of cellular recognition and serological specificities. The feasibility of utilizing synthetic peptides as protective immunogenic and therapeutic reagents will also be investigated. In these cases, peptides corresponding to portions of viral
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