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Related post: Dr. Mark Tykocinski
Chemist
Staff Fellow
Med. Staff Fellow
LIG, NIAID
COOPERATING UNITS (if any)
T. Chused, LMI , NIAID, J. Purchase Trileptal Coe, Rocky Mountain Laboratory, NIAID,
P. A. Cazenave, Institut Pasteur, Paris, France
lab/branch
Laboratory of Immunogenetics
SECTION
Immunogenetics Research Trileptal Online Secrinn
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MD 20205
TOTAL MANYEARS:
2.4
PROFESSIONAL:
1.6
OTHER:
0.
CHECK APPROPRIATE BOX(ES)
D (a) HUMAN SUBJECTS
n (al) Oxcarbazepine Trileptal MINORS n (a2) INTERVIEWS
D (b) HUMAN TISSUES
n (c) NEITHER
SUMMARY OF WORK (200 words or less - underline keywords)
A set of monoclonal antibodies prepared has been used in biochemical and
functional analysis of rabbit lyirphoid cell subpopulations . Detailed study
has defined a small group of the monoclonal antibodies which recognize
distinct cell surface molecules and define among them si±)sets of T cells in
the thymus and periphery as well as subsets of B cells. Immunoprecipitation
of labeled surface rtDlecules has defined the antigens v^ile the cell sorter
has been-used for cellular analysis. A number of antigen-specific rabbit T
cell lines have been developed to characterize rabbit T cell responses Generic Trileptal to the
These lines are being propagated for studies on
The kappa
group C streptococcus.
antigen-binding molecules and restriction in antigen presentation.
chain allotypes of wild rabbits (b97, b98) are under Trileptal Mg structural study in
collaborative experiments. The hamster seirum protein FP (female protein) has
also been partially characterized in sequence studies.
I 19-12
PHS-6040
(Rev. 2-81)
SMITHSONIAN SCIENCE INFORMATION EXCHANGE
PROJECT NUMBER (Do NOT use this space)
U.S. DEPARTMENT OF
HEALTH AND HUMAN SERVICES
PUBLIC HEALTH SERVICE
NOTICE OF
INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl-AI-00172-05 LIG
PERIOD COVERED
October 1. 1981 to September 30. 1982
TITLE OF PROJECT (80 characters or less)
Structure and Synthesis of Peptides
NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT
Section Head
PI: Dr. JohnE. Coligan
Others: Dr. W.'Lee Maloy Staff Trileptal For Children Fellow
Dr. Marie R. Van Schravendi j k Visiting Fellow
LIG, NIA
ID
COOPERATING UNITS (if any)
lab/branch
Laboratory of Immunogeneti cs
SECTION
Membrane Antigen Structure
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MP 20205
TOTAL MANYEARS:
2.5
PROFESSIONAL:
1 .5
1.0
CHECK APPROPRIATE BOX(ES)
n Trileptal 900 Mg (a) HUMAN SUBJECTS
n (al) MINORS D (a2) INTERVIEWS
D (b) HUMAN TISSUES
[i^(c) NEITHER
SUMMARY OF WORK (200 words or less - underline keywords)
Through protein and DNA sequence analyses, much information on Trileptal 300 Mg the primary
structure of membrane bound proteins has accummalated over the past several
years. It is proposed Trileptal Price to utilize this information to prepare antibodies
reactive with defined portions of these molecules. This will be done by
synthesizing 10-20 residue peptides that correspond to Trileptal Oxcarbazepine sections of the sequence
of the membrane bound proteins. After coupling to a carrier Generic For Trileptal protein, antisera
to these peptides will be prepared. In the case of Trileptal Generic transplantation and other
lyrtphocyte antigens, these antibodies will be used to define sites of cellular
recognition and serological specificities. The feasibility of utilizing
synthetic peptides as protective immunogenic and therapeutic reagents will also
be investigated. In these cases, peptides corresponding to portions of viral
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